{"id":2796,"date":"2024-07-30T20:46:15","date_gmt":"2024-07-30T20:46:15","guid":{"rendered":"https:\/\/daslab-tmp.su.domains\/?page_id=2796"},"modified":"2024-09-04T23:12:47","modified_gmt":"2024-09-04T23:12:47","slug":"research","status":"publish","type":"page","link":"https:\/\/daslab-tmp.su.domains\/?page_id=2796","title":{"rendered":"Research"},"content":{"rendered":"

[vc_row][vc_column][vc_column_text]<\/p>\n

Our lab strives to<\/strong> model and design the RNA sequences that define and regulate living systems.<\/div>\n

[\/vc_column_text][vc_row_inner equal_height=”yes” content_placement=”middle” css=”.vc_custom_1724282918977{border-bottom-width: 1px !important;border-bottom-color: #666666 !important;border-bottom-style: dotted !important;}” el_class=”mobile-col-swap research-items”][vc_column_inner width=”1\/3″][vc_column_text]<\/p>\n

3D Puzzles<\/div>\n

[\/vc_column_text][\/vc_column_inner][vc_column_inner width=”1\/3″][vc_column_text el_class=”justify-text-block”]We develop algorithms to predict the structures and energetics of RNAs and RNA\/protein interfaces with high accuracy. We test these ideas through community-wide blind trials; by enhancing NMR, crystallographic, and cryoelectron microscopy methods; and by designing new nanostructures.[\/vc_column_text][\/vc_column_inner][vc_column_inner width=”1\/3″][vc_single_image image=”3983″ img_size=”full” alignment=”right”][\/vc_column_inner][\/vc_row_inner][vc_row_inner equal_height=”yes” content_placement=”middle” css=”.vc_custom_1724282928158{border-bottom-width: 1px !important;border-bottom-color: #666666 !important;border-bottom-style: dotted !important;}” el_class=”mobile-col-swap research-items”][vc_column_inner width=”1\/3″][vc_column_text]<\/p>\n

RNA structures<\/div>\n

[\/vc_column_text][\/vc_column_inner][vc_column_inner width=”1\/3″][vc_column_text el_class=”justify-text-block”]Complementary to our computational research, we are developing information-rich biochemical methods to model the myriad structures of non-coding RNAs that remain unknown. Current efforts focus on probing the extent of RNA structure and conformational change inside cells and viruses, in close collaboration with expert biologists at Stanford. [\/vc_column_text][\/vc_column_inner][vc_column_inner width=”1\/3″][vc_single_image image=”3982″ img_size=”full” alignment=”right”][\/vc_column_inner][\/vc_row_inner][vc_row_inner equal_height=”yes” content_placement=”middle” el_class=”mobile-col-swap research-items”][vc_column_inner width=”1\/3″][vc_column_text]<\/p>\n

Cloud Biochemistry<\/div>\n

[\/vc_column_text][\/vc_column_inner][vc_column_inner width=”1\/3″][vc_column_text el_class=”justify-text-block”]We aim to design new RNA molecules for basic science, diagnostics, and therapeutics. Our videogame project Eterna seeks missing rules and novel molecules for medicine by giving citizen scientists access to high-throughput wet-lab experiments.[\/vc_column_text][\/vc_column_inner][vc_column_inner width=”1\/3″][vc_single_image image=”3981″ img_size=”full” alignment=”right”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row][vc_column][vc_column_text] Our lab strives to model and design the RNA sequences that define and regulate living systems. [\/vc_column_text][vc_row_inner equal_height=”yes” content_placement=”middle” css=”.vc_custom_1724282918977{border-bottom-width: 1px !important;border-bottom-color: #666666 !important;border-bottom-style: dotted !important;}” el_class=”mobile-col-swap research-items”][vc_column_inner width=”1\/3″][vc_column_text] 3D Puzzles [\/vc_column_text][\/vc_column_inner][vc_column_inner width=”1\/3″][vc_column_text el_class=”justify-text-block”]We develop algorithms to predict the structures and energetics of RNAs and RNA\/protein interfaces with high accuracy. We test these ideas […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2796","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=\/wp\/v2\/pages\/2796","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2796"}],"version-history":[{"count":0,"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=\/wp\/v2\/pages\/2796\/revisions"}],"wp:attachment":[{"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2796"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}