{"id":3104,"date":"2019-12-03T21:00:17","date_gmt":"2019-12-03T21:00:17","guid":{"rendered":"https:\/\/daslab-tmp.su.domains\/?p=3104"},"modified":"2024-07-31T21:08:34","modified_gmt":"2024-07-31T21:08:34","slug":"in-collaboration-with-wah-chius-lab-were-pushing-the-limits-of-cryo-em-single-particle-analysis-to-solve-structures-an-article-in-nature-communications-describes-our-results-on-a-40-kda-rna-the","status":"publish","type":"post","link":"https:\/\/daslab-tmp.su.domains\/?p=3104","title":{"rendered":"In collaboration with Wah Chiu&#8217;s lab, we&#8217;re pushing the limits of cryo-EM single-particle analysis to solve structures. An article in Nature Communications describes our results on a 40 kDa RNA, the SAM-IV riboswitch aptamer. The paper includes analyses confirming that the ligand-binding site can be detected in the RNA. Come play the Eterna puzzle celebrating this beautiful molecule (worth 500 points)"},"content":{"rendered":"<p>In collaboration with Wah Chiu&#8217;s lab, we&#8217;re pushing the limits of\u00a0<b>cryo-EM single-particle analysis<\/b>\u00a0to solve structures. An article in\u00a0<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13494-7\" target=\"_blank\" rel=\"noopener\">Nature Communications<\/a>\u00a0describes our results on a 40 kDa RNA, the SAM-IV riboswitch aptamer. The paper includes analyses confirming that the ligand-binding site can be detected in the RNA. Come play the\u00a0<a href=\"https:\/\/eternagame.org\/web\/puzzle\/9648254\/\" target=\"_blank\" rel=\"noopener\">Eterna puzzle<\/a>\u00a0celebrating this beautiful molecule (worth 500 points)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In collaboration with Wah Chiu&#8217;s lab, we&#8217;re pushing the limits of\u00a0cryo-EM single-particle analysis\u00a0to solve structures. An article in\u00a0Nature Communications\u00a0describes our results on a 40 kDa RNA, the SAM-IV riboswitch aptamer. The paper includes analyses confirming that the ligand-binding site can be detected in the RNA. Come play the\u00a0Eterna puzzle\u00a0celebrating this beautiful molecule (worth 500 points)<\/p>\n","protected":false},"author":1,"featured_media":3155,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-3104","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=\/wp\/v2\/posts\/3104","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3104"}],"version-history":[{"count":0,"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=\/wp\/v2\/posts\/3104\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=\/wp\/v2\/media\/3155"}],"wp:attachment":[{"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3104"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3104"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3104"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}