{"id":3110,"date":"2020-03-28T21:00:21","date_gmt":"2020-03-28T21:00:21","guid":{"rendered":"https:\/\/daslab-tmp.su.domains\/?p=3110"},"modified":"2024-07-31T21:13:01","modified_gmt":"2024-07-31T21:13:01","slug":"to-aid-in-the-design-of-nucleic-acid-based-therapeutics-for-the-raging-covid-19-pandemic-ramya-rangan-and-ivan-vanya-zheludev-have-worked-quickly-to-conduct-a-comprehensive-conservation-analysis-of","status":"publish","type":"post","link":"https:\/\/daslab-tmp.su.domains\/?p=3110","title":{"rendered":"To aid in the design of nucleic acid-based therapeutics for the raging COVID-19 pandemic, Ramya Rangan and Ivan (Vanya) Zheludev have worked quickly to conduct a comprehensive conservation analysis of the SARS-CoV-2 genome. Their preprint, published today in bioRxiv, identifies in this RNA virus many highly conserved sequences and secondary structure. A follow-up analysis confirms the conservation of many of these regions in the 739 SARS-CoV-2 genomes published during the current outbreak. The regions they have identified provide promising targets for the development of antiviral anti-sense oligonucleotide treatments as we continue to fight the COVID-19 pandemic."},"content":{"rendered":"<p>To aid in the design of nucleic acid-based therapeutics for the raging COVID-19 pandemic,\u00a0<b>Ramya Rangan<\/b>\u00a0and\u00a0<b>Ivan (Vanya) Zheludev<\/b>\u00a0have worked quickly to conduct a comprehensive conservation analysis of the SARS-CoV-2 genome. Their preprint,\u00a0<a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2020.03.27.012906v1\" target=\"_blank\" rel=\"noopener\">published today in bioRxiv<\/a>, identifies in this RNA virus many highly conserved sequences and secondary structure. A follow-up analysis confirms the conservation of many of these regions in the 739 SARS-CoV-2 genomes published during the current outbreak. The regions they have identified provide promising targets for the development of antiviral anti-sense oligonucleotide treatments as we continue to fight the COVID-19 pandemic.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>To aid in the design of nucleic acid-based therapeutics for the raging COVID-19 pandemic,\u00a0Ramya Rangan\u00a0and\u00a0Ivan (Vanya) Zheludev\u00a0have worked quickly to conduct a comprehensive conservation analysis of the SARS-CoV-2 genome. Their preprint,\u00a0published today in bioRxiv, identifies in this RNA virus many highly conserved sequences and secondary structure. A follow-up analysis confirms the conservation of many of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3165,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-3110","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=\/wp\/v2\/posts\/3110","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3110"}],"version-history":[{"count":0,"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=\/wp\/v2\/posts\/3110\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=\/wp\/v2\/media\/3165"}],"wp:attachment":[{"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3110"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3110"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/daslab-tmp.su.domains\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3110"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}